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Proceedings of the 11th Paris Hepatology Conference. International Conference on the Management of Liver Diseases
Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?
Tarik Asselah, Patrick Marcellin, Raymond F. Schinazi
Around 71 million people are chronically infected with HCV worldwide. HCV antiviral drug development has been remarkable. The availability of pangenotypic direct-acting antivirals with excellent efficacy and good tolerability profiles offer a unique opportunity to achieve HCV elimination worldwide. IFN-free DAA combinations can now cure HCV in more than 95% of patients with HCV infection after 8-12 weeks of treatment. Programmes to eliminate HCV must include increased screening (risk-based and universal), linkage to care, as well as increased access to treatment worldwide. In this paper, we will review the available data on recently approved direct-acting antiviral agents, with sustained virological response that reaches almost 100%.